The cees dekker Diaries
The cees dekker Diaries
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2009, discovery of a whole new phenotype for germs in slim nanofluidic slits; and 1st detection of community protein buildings together DNA applying good-point out nanopores
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Non-equilibrium folding of unique DNA molecules recaptured nearly one thousand instances within a sound state nanopore
That is a aspiration of mine and we established to work by using a delicious dose of naivety. This can be a thing that will probably yield magnificent ends in the for a longer period phrase, but that does not make any difference. You should not only want to work on the queries of tomorrow, and also on the queries on the working day after tomorrow.’
Our analysis ranges from your biophysics of DNA to synthetic cells and past. Make sure you have a look below at the spectrum of our current jobs.
‘In the beginning we checked out biological programs which has a physical check out and acted on The idea of your tools we understood. It took a several years right before we began Doing work additional on the massive biological problems. I then started to phone it nanobiology, a expression that didn't exist at some time.
Nanopores stand for an elegant and flexible Instrument to measure one molecules. We research novel detection modes with good-point out nanopores and many tips on how to evaluate proteins with nanopores. Initiatives encompass the next:
Understanding fundamental procedures regulating the spatial and dynamic organisation of the DNA in Reside cells.
‘The fantastically refined way where aspects in character function never ceases to amaze me. If we address the puzzle of how lifetime came into being, I hope that my amazement for the complexity of development will have amplified and with it my awe to the greatness from the Creator.’
Screening pseudotopological and nontopological products for SMC-driven DNA loop extrusion in opposition to roadblock-traversal experiments
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2008, to start with observation of protein-coated DNA translocation as a result of nanopores; fixed the origin with the electrophoretic pressure on DNA in nanopores; uncovered a major velocity enhance of microtubules in electrical fields; found an anomalous electro-hydrodynamic orientation of microtubules; and resolved the origin of sounds in carbon nanotubes in liquid
2004, discovery of new physics in translocation of DNA as a result of nanopores; 1st experimental ceesdekker study of ions conduction in nanofluidic channels; to start with electrochemistry with specific single-wall carbon nanotubes; STM detection and Charge of phonons in carbon nanotubes; initial electrical docking of microtubules on kinesin-coated nanostructures; initially biophysics characterization in the mechanical properties of double-stranded RNA; and 1st single-molecule review of DNA translocation by a restriction-modification enzyme.